Phenotype Image Detail

Image

Caption

Cerebral arteriovenous malformations (AVMs) in Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0 mice. A, B. Gross morphology of control (A) and mutant (B) P3 mouse heads. Irregular and tortuous blood vessels were evident in the surface of mutant heads. C, D. Corrosion casts of blood vessels in the control and mutant brains demonstrate multiple AVM lesions in the mutant brains. The inset shows a magnified view of blood vessels in the hippocampus area. E, F. H&E staining of coronal sections of brains show dilated vessels in subdural areas (arrows) and hemorrhages in the hippocampus area (arrow with an asterisk). Scale bars indicate 2 mm (A-D), 1 mm (E, F), 0.5 mm (D inset), and 250 um (F inset).

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Tg(Acvrl1-cre)L1Spo	transgene insertion L1, S Paul Oh

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Tg(Acvrl1-cre)L1Spo/0	involves: 129 * FVB