Phenotype Image Detail

Image

Caption

Blood flow through patent arteriovenous (AV) fistulas. Vascular images by latex dye injection via left heart of control (A) and Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ (B) mice demonstrate AV shunts in the mutants where latex dye was found in both arteries and veins. (C) Direction of blood flow obtained from video recording is indicated by arrows. Yellow asterisks indicate an area of vein at the receiving end of AV shunts showing dilated and tortuous vessel morphology. (D and E) Fluorescence images of blood flow in 2 AVM areas labeled as D and E in C. Black arrows in D indicate the direction of blood flow. Arrowheads indicate an AVM vessels showing leakage of blood. Yellow asterisks in E indicate a venous area having turbulent blood flow and corresponding vessel tortuosity. The blue arrows in D and E indicate the same area of blood vessel. Scale bars: 1 mm (A and B); 0.5 mm (C); 100 um (D); 200 um (E).

Copyright

This image is from Park SO, J Clin Invest 2009 Nov;119(11):3487-96 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:154620

Associated Alleles

Symbol	Name
Acvrl1^tm2.1Spo	activin A receptor, type II-like 1; targeted mutation 2.1, S Paul Oh
Gt(ROSA)26Sor^tm1(cre/ERT)Nat	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jeremy Nathans

Associated Genotypes

Allelic Composition	Genetic Background
Acvrl1^tm2.1Spo/Acvrl1^tm2.1Spo Gt(ROSA)26Sor^tm1(cre/ERT)Nat/Gt(ROSA)26Sor^+	involves: 129 * 129S1/Sv * 129X1/SvJ