Phenotype Image Detail

Image

Caption

Immunofluorescent staining of P5 Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1⁺/Nkx3-1⁺ (Klf^f/fNkx3.1^+/+; control) anterior prostates showed similar expression of early smooth muscle marker, smooth muscle actin (SMA) and late marker (A and C), desmin lining the ducts (E and G) but absent in areas where new lateral branches were formed (arrow). In Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms Nkx3-1⁺ (Klf^f/fNkx3.1^Cre/+; mutant) anterior prostates, SMA (B and D) and desmin (F and H) were expressed continuously along the entire length of the main ducts except for the distal tip (arrowhead). Low magnification (A, B, E, and F) and high magnification (C, D, G, and H) of respective images. Bar, 100 um for A, B, E, and F, and 50 um for C, D, G, and H.

Copyright

This image is from Leow CC, J Biol Chem 2009 Jul 31;284(31):21057-65 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:153183

Associated Alleles

Symbol	Name
Klf6^tm1Fjs	Kruppel-like transcription factor 6; targeted mutation 1, Frederic J de Sauvage
Nkx3-1^tm3(cre)Mms	NK3 homeobox 1; targeted mutation 3, Michael M Shen

Associated Genotypes

Allelic Composition	Genetic Background
Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1^+	involves: 129/Sv * C57BL/6
Klf6^tm1Fjs/Klf6^tm1Fjs	involves: 129 * C57BL/6