Phenotype Image Detail

Image

Caption

Analysis of collagen in mice tendons. Atomic force microscopy of control male and female mouse tail tendon samples show ordered and regular banding. Vipas39^{tm1c(KOMP)Mbp}/Vipas39^{tm1c(KOMP)Mbp} Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ (Vipas39^fl/fl-ER^T2) shows a large increase in height from control, with the swelling causing large jumps in the profile. Vps33b^tm1.1Arte/Vps33b^tm1.1Arte Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ (Vps33b^fl/fl-ER^T2) shows a greater level of distortion than other samples with a far more irregular profile and height variation. Arrows indicate examples of distortion on the graphs in the area of line profile analysis (blue line).

Copyright

This image is from Banushi B, Nat Commun 2016 Jul 20;7():12111, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:236095

Associated Alleles

Symbol	Name
Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks
Vipas39^tm1c(KOMP)Mbp	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog; targeted mutation 1c, Mouse Biology Program, UC Davis
Vps33b^tm1.1Arte	vacuolar protein sorting 33B; targeted mutation 1.1, TaconicArtemis

Associated Genotypes

Allelic Composition	Genetic Background
Vps33b^tm1.1Arte/Vps33b^tm1.1Arte Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6J
Vipas39^tm1c(KOMP)Mbp/Vipas39^tm1c(KOMP)Mbp Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj/Gt(ROSA)26Sor^+	involves: C57BL/6 * C57BL/6J * C57BL/6N