Phenotype Image Detail

Image

Caption

Bright and fluorescent images of PECAM-1 immunostained E9.5-10.5 (a) wild-type and (b) Aldh1a2^grim/Aldh1a2^grim (grimace) embryos. Arrowheads and arrows indicate perturbed pharyngeal arch artery formation and anomalies in vascular plexus development, respectively. Mutant embryos lack caudal pharyngeal arch arteries and exhibit diminished cranial vascular plexi.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Aldh1a2^grim	aldehyde dehydrogenase family 1, subfamily A2; grimace

Associated Genotypes

Allelic Composition	Genetic Background
Aldh1a2^grim/Aldh1a2^grim	involves: 129S1/Sv * C57BL/6 * FVB/NJ