Phenotype Image Detail

Image

Caption

Bright and fluorescent images of Neurofilament of beta-tubulin innunostained E9.5-10.5 (a) wild-type and (b) Aldh1a2^grim/Aldh1a2^grim (grimace) embryos. Arrowheads and arrows highlight agenesis or hypoplasia of neuronal differentiation in the midbrain and cranial ganglia. Neurofilament staining reveals near complete nervous system agenesis. Except for a small amount of neurofilament staining at the isthmus, there is no evidence of the neuronal network or plexus that typically develops in the midbrain (arrowhead). Defects in peripheral nervous system development are similarly extreme. Except for a couple of very discrete localized domains of neurofilament staining adjacent to the hindbrain, there is little evidence of any overt neural differentiation in association with the cranial ganglia. Abbreviations: pl, plexus; f, facioacoustic/vestibule cochlear; g, glossopharyngeal; tg, trigeminal; v. vagal.

Copyright

This image is from Sandell LL, Genesis 2011 Apr;49(4):342-59, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:171522

Associated Alleles

Symbol	Name
Aldh1a2^grim	aldehyde dehydrogenase family 1, subfamily A2; grimace

Associated Genotypes

Allelic Composition	Genetic Background
Aldh1a2^grim/Aldh1a2^grim	involves: 129S1/Sv * C57BL/6 * FVB/NJ