Phenotype Image Detail

Image

Caption

(a, b) Photographs of Bicd2^tm1.1Hgrd/Bicd2^tm1.1Hgrd (Bicd2-/-) mice showing a normal gross appearance at embryonic day 19 (a) and a dome-shaped head indicative of hydrocephalus at post-natal day 20 (b). (d) Coronal brain sections of P20 mice stained for LacZ and neutral red reveal enlarged lateral ventricles (LV), thinning of the cortex (Cx) and atrophy of several telencephalic areas including striatum (Str) and lateral septum (LS) in homozygote mutant mice and no change in heterozygote mutant mice. Note the moderate and high level of LacZ staining throughout the forebrain of heterozygous and homozygous mice, respectively, indicative of widespread BICD2 expression.

Copyright

This image is from Jaarsma D, Nat Commun 2014;5():3411, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:210236

Associated Alleles

Symbol	Name
Bicd2^tm1.1Hgrd	BICD cargo adaptor 2; targeted mutation 1.1, Casper Hoogenraad

Associated Genotypes

Allelic Composition	Genetic Background
Bicd2^tm1.1Hgrd/Bicd2^tm1.1Hgrd	involves: C57BL/6