Phenotype Image Detail

Image

Caption

Synj2^mozart/Synj2^mozart (Synj2^N538K/^N538K) cochleae exhibit degeneration. Wild-type (Synj2^+/+) (Panels A, B and C) and mutant (Panels D, E and F) cochleae were sectioned at 4 (Panels A and D), 8 (Panels B and E) and 12 (Panels C and F) weeks of age and H&E stained. Representative cochleae are shown. Mutant cochleae show signs of degeneration at 8 and 12 weeks of age, with evidence of collapse of the organ of Corti (arrow head, panels E and F) and degeneration of spiral ganglion neurons (arrow, panels E and F). SG, spiral ganglion; OC, organ of corti; OHC, outer hair cells; IHC, inner hair cell. Scale bar: 100 um.

Copyright

This image is from Manji SS, PLoS One 2011;6(3):e17607, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:171701

Associated Alleles

Symbol	Name
Synj2^mozart	synaptojanin 2; mozart

Associated Genotypes

Allelic Composition	Genetic Background
Synj2^mozart/Synj2^mozart	C57BL/6-Synj2^mozart