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Phenotype Image Detail
Image
Caption Ferritin expression is increased in Ireb2tm1.1Eal/Ireb2tm1.1Eal (Irp2-/-) neurons. Double immuno-fluorescence labeling of brain sections from male mutant and wild-type (WT) mice using ferritin antibody with either calbindin (Purkinje specific) or NeuN (neuronal nuclei) antibodies. A) Calbindin immunofluorescence shows that Purkinje cell number and morphology (yellow arrows, processes), are normal in the mutant cerebellum. B) Ferritin and calbindin double immune-fluorescence of cerebellum shows similar ferritin expression in mutant and WT Purkinje neurons. C) Ferritin and NeuN double immunofluorescence of hippocampal CA1 pyramidal cell layer, and D) caudate putamen shows increased ferritin expression in neuronal cell bodies (yellow arrows) of mutant mice compared to WT mice. Increased ferritin staining is observed in the neuropil in the hippocampus and caudate putamen of mutant mice. Scale bars: 50 um.
Copyright This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335
Associated
Alleles
Symbol Name
Ireb2tm1.1Eal iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
Associated
Genotypes
Allelic Composition Genetic Background
Ireb2tm1.1Eal/Ireb2tm1.1Eal B6J.129-Ireb2tm1.1Eal

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory