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Phenotype Image Detail
Image
Caption Iron is reduced in Purkinje neurons and in CA1 pyramidal neurons of Ireb2tm1.1Eal/Ireb2tm1.1Eal (Irp2-/-) mice. A) Perls' diaminobenzidine (DAB)-enhanced iron staining in CA1 pyramidal neurons and Purkinje neurons in mutant and wild-type (WT) mice (Pkj, Purkinje; gl, granular layer; wm, white matter). B) Quantification of Perls' staining of images in (A) was carried out by measuring staining intensity in a defined subsection of brains from mutant (n = 10) and WT (n = 8). Data are given as the mean +/- SEM; *p,0.05; ***p,0.001 relative to WT. Scale bars: 25 um and 50 um.
Copyright This image is from Zumbrennen-Bullough KB, PLoS One 2014;9(6):e98072, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:217335
Associated
Alleles
Symbol Name
Ireb2tm1.1Eal iron responsive element binding protein 2; targeted mutation 1.1, Elizabeth A Leibold
Associated
Genotypes
Allelic Composition Genetic Background
Ireb2tm1.1Eal/Ireb2tm1.1Eal B6J.129-Ireb2tm1.1Eal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory