Phenotype Image Detail

Image

Caption

Liver histology, weight, and triglyceride content in wild-type (WT) and Tg(Fabp4-LMNA*R482Q)11ACdl/0 (FPLD) mice at 32 weeks of age on a high fat diet. (A) Gross pathology of livers from representative control (left) and FPLD (right) mice at 32 weeks of age on a high fat diet. (B) Hemotoxylin and eosin stained sections of livers from representative control (left) and FPLD (right) mice at 32 weeks of age on high-fat diet. (C) Liver weight expressed as percentage of total body weight from control and FPLD mice at 32 weeks of age on a high-fat diet (n = 6/group). FPLD livers weighed significantly more than livers from control animals (*P = 0.0004). (D) Triglyceride content of livers from control and FPLD mice at 32 weeks of age on high-fat diet (n = 4-6/group). Livers from FPLD mice had significantly more triglyceride per gram of liver than control mice (*P = 0.006). Data are expressed as averages +/- SEM.

Copyright

This image is from Wojtanik KM, J Lipid Res 2009 Jun;50(6):1068-79 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text is from JLR. J:149858

Associated Alleles

Symbol	Name
Tg(Fabp4-LMNA*R482Q)11ACdl	transgene insertion 11A, Constantine D Londos

Associated Genotypes

Allelic Composition	Genetic Background
Tg(Fabp4-LMNA*R482Q)11ACdl/0	FVB-Tg(Fabp4-LMNA*R482Q)11ACdl