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Phenotype Image Detail
Image
Caption (A) Skeletal stain at P0 showing hindlimb and forelimb phalange development in the wild-type, Sostdc1tm2Snd/Sostdc1tm2Snd (Wise-/-), Lrp5tm1Kry/Lrp5tm1Kry (Lrp5-/-), Sostdc1tm2Snd/Sostdc1tm2Snd Lrp5tm1Kry/Lrp5tm1Kry (Wise-/-:Lrp5-/-) and Lrp6+/- strains. (B) Asterisks (*) highlight an increase in the ossification centers of digits 4 and 5 of the hindlimb in Wise-/- mutants compared to the other strains. This Wise-/- mutant phenotype in digits is partially rescued in an Lrp5-/- strain showing an epistatic relationship between Wise and Lrp5. n = at least 5.
Copyright This image is from Ellies DL, PLoS One 2014;9(5):e96257, an open-access article distributed under the terms of the Creative Commons Attribution License. J:216098
Associated
Alleles
Symbol Name
Lrp5tm1Kry low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
Sostdc1tm2Snd sclerostin domain containing 1; targeted mutated 2, Scott Sunders
Associated
Genotypes
Allelic Composition Genetic Background
Sostdc1tm2Snd/Sostdc1tm2Snd involves: 129S/SvEv
Lrp5tm1Kry/Lrp5tm1Kry
Sostdc1tm2Snd/Sostdc1tm2Snd
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory