Phenotype Image Detail

Image

Caption

Presence of inflammatory cells in the pancreas associated with the cystic structures. Immunohistochemistry revealed the presence of different populations of leucocytes infiltrating the pancreas of a 20-day-old Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre LSL-Kras^G12D Tif1gamma^lox/lox) mouse (D-F) compared to a wild-type littermate (A-C). MPO (A,D), F4/80 (B,E), and CD3 (C,F) were respectively used as specific markers for neutrophils, macrophages and lymphocytes.

Copyright

This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781

Associated Alleles

Symbol	Name
Kras^tm4Tyj	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Tg(Pdx1-cre)89.1Dam	transgene insertion 89.1, Douglas A Melton
Trim33^tm1Los	tripartite motif-containing 33; targeted mutation 1, Regine Losson

Associated Genotypes

Allelic Composition	Genetic Background
Kras^tm4Tyj/Kras^tm4Tyj Trim33^tm1Los/Trim33^tm1Los Tg(Pdx1-cre)89.1Dam/0	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2