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Phenotype Image Detail
Image
Caption (A) Yolk sac and embryo morphology of control and Bmp10tm1.1(Gdf2)Minh/Bmp10tm1.1(Gdf2)Minh (Bmp109/9) mice at different stages. (B) Heart gross morphology and histology of control and homozygous mutant animals at E17.5. Up to E16.5, mutant embryos did not exhibit any gross developmental defects. Starting around E16.5, mutants were affected by apparent hemorrhage and edema, with increased severity in older embryos. At E17.5, the gross morphology of the heart became overtly abnormal, with enlarged size and altered shape (B). A majority of mutant hearts also presented with ventricular septal defects (B).
Copyright This image is from Chen H, Proc Natl Acad Sci U S A 2013 Jul 16;110(29):11887-92. Copyright 2013 National Academy of Sciences, U.S.A. J:222016
Associated
Alleles
Symbol Name
Bmp10tm1.1(Gdf2)Minh bone morphogenetic protein 10; targeted mutation 1.1, Minhong Yan
Associated
Genotypes
Allelic Composition Genetic Background
Bmp10tm1.1(Gdf2)Minh/Bmp10tm1.1(Gdf2)Minh C57BL/6N-Bmp10tm1.1(Gdf2)Minh

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last database update
04/16/2019
MGI 6.13
The Jackson Laboratory