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Phenotype Image Detail
Image
Caption Neutralization of BMP10 causes defective vascular development in Gdf2tm1Lex/Gdf2+ (Bmp9+/-) and Gdf2tm1Lex/Gdf2tm1Lex (Bmp9-/-) mice. (A) Fluorescence images of low (Top) and higher magnification (Middle and Bottom) of retinal vasculature. Neonatal mice were treated with PBS or anti-BMP10 (462732; R&D Systems) on P2 and P4, at 10 mg/kg. Whole mount P7 mouse retinas were stained with isolectin B4 to visualize overall vasculature, and anti-alphaSMA for arteries. Dotted line at Middle marks the edge of retinal cup. (Scale bars: Top, 500 um; Middle, 200 um; Bottom, 25 um.)
Copyright This image is from Chen H, Proc Natl Acad Sci U S A 2013 Jul 16;110(29):11887-92. Copyright 2013 National Academy of Sciences, U.S.A. J:222016
Associated
Alleles
Symbol Name
Gdf2tm1Lex growth differentiation factor 2; targeted mutation 1, Lexicon Genetics
Associated
Genotypes
Allelic Composition Genetic Background
Gdf2tm1Lex/Gdf2tm1Lex involves: 129S5/SvEvBrd * C57BL/6
Gdf2tm1Lex/Gdf2+ involves: 129S5/SvEvBrd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory