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Phenotype Image Detail
Image
Caption H&E staining of the gastrocnemius muscle of wild-type (CTL) and Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSTWT) and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ (CAG-FUSR521G) mice at end stage show wasting of the muscle and scattered and grouped muscle atrophy, characteristic of motor axon degeneration. Arrowheads indicate pyknotic myofibers. Images are representative of three animals per genotype.
Copyright This image is from Sephton CF, Proc Natl Acad Sci U S A 2014 Nov 4;111(44):E4769-78. Copyright 2014 National Academy of Sciences, U.S.A. J:216672
Associated
Alleles
Symbol Name
Meox2tm1(cre)Sor mesenchyme homeobox 2; targeted mutation 1, Philippe Soriano
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu transgene insertion 629, Gang Yu
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu transgene insertion 682, Gang Yu
Associated
Genotypes
Allelic Composition Genetic Background
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS,-EGFP)629Gyu/0
involves: 129S4/SvJaeSor * C57BL/6
Meox2tm1(cre)Sor/Meox2+
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0
involves: 129S4/SvJaeSor * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory