Phenotype Image Detail

Image

Caption

Genetic interaction between Bmp4 and Bmp7 during the caudal body formation. (C-D) Whole-mount view and (G-H) mid-sagittal sections of wild-type (WT) and Bmp4^tm4Blh/Bmp4⁺ Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra Hoxa3^tm1(cre)Moon/Hoxa3⁺ (mutant) embryos. Red arrowheads indicate the hindlimb position. (D). The compound mutant mice show bladder aplasia (H) and anal stenosis (arrow in H). dGT, dorsal GT; b, bladder; r, rectum.

Copyright

This image is from Suzuki K, PLoS One 2012;7(9):e43453, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192045

Associated Alleles

Symbol	Name
Bmp4^tm4Blh	bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
Bmp7^tm1.1Dgra	bone morphogenetic protein 7; targeted mutation 1.1, Daniel Graf
Hoxa3^tm1(cre)Moon	homeobox A3; targeted mutation 1, Anne M Moon

Associated Genotypes

Allelic Composition	Genetic Background
Bmp4^tm4Blh/Bmp4^+ Bmp7^tm1.1Dgra/Bmp7^tm1.1Dgra Hoxa3^tm1(cre)Moon/Hoxa3^+	involves: 129S6/SvEvTac * C57BL/6NTac