Phenotype Image Detail

Image

Caption

Hindlimb fusion of Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1⁺ (Bmp4 cKO) mice. (F-J) Hindlimb fusion shown by gross appearance and by skeletal preparations of mutant mice. The fibulae are aberrantly located medially (I) or are absent (J) in the mutants. Red arrowheads indicate the ossified fibula.

Copyright

This image is from Suzuki K, PLoS One 2012;7(9):e43453, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192045

Associated Alleles

Symbol	Name
Bmp4^tm4Blh	bone morphogenetic protein 4; targeted mutation 4, Brigid L Hogan
Isl1^tm1(cre)Sev	ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Sylvia Evans

Associated Genotypes

Allelic Composition	Genetic Background
Bmp4^tm4Blh/Bmp4^tm4Blh Isl1^tm1(cre)Sev/Isl1^+	involves: 129 * 129S6/SvEvTac