Phenotype Image Detail

Image

Caption

Morphology of orthotopic and ectopic dentary bones and middle ear structures in wild-type (WT) and Ednra^tm6(Edn1)Hku/Ednra⁺ (Ednra^Edn1/+) mice. (A and B) Orthotopic dentary bones and middle ear structures of E18.5 WT (A) and mutant (B) mice. In mutant mice, the coronoid and condylar processes are hypoplastic and the anterior part of the ectotympanic is hyperplastic. The stapes is fused to the styloid process in mutants. (C and D) Upper jaw components of E18.5 WT (C) and mutant (D) mice. In the maxillary region of mutant mice, a dentary-like bone with angular, condylar, and coronoid processes is formed. The tip of the ectopic dentary extends anteriorly and fuses to the premaxilla. agp, angular process, cdp, condylar process; crp, coronoid process; dnt, dentary; etm, ectotympanic; fmx, frontal process of maxilla; gn, gonial; in, incus; jg, jugal; la, lacrimal; LI, lower incisor; ma, malleus; MC, Meckel's cartilage; moa, molar alveolus; mx, maxilla; pmx, premaxilla; sp, styloid process; st, stapes; UI, upper incisor; *, ectopic structure.

Copyright

This image is from Sato T, Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18806-11. Copyright 2008 National Academy of Sciences, U.S.A. J:224515

Associated Alleles

Symbol	Name
Ednra^tm6(Edn1)Hku	endothelin receptor type A; targeted mutation 6, Hiroki Kurihara

Associated Genotypes

Allelic Composition	Genetic Background
Ednra^tm6(Edn1)Hku/Ednra^+	involves: 129 * C57BL/6 * ICR