Phenotype Image Detail

Image

Caption

Snx10^{tm1a(EUCOMM)Raba}/Snx10^{tm1a(EUCOMM)Raba} (Snx10 KD) and Tcirg1^tm1Ypl/Tcirg1^tm1Ypl (Atp6i KO) mice show a combined phenotype: osteopetrorickets. A) Radiographs (top and bottom panels) show that both mutant mice have bones with a higher radio-density and lack cortical bone. The metaphyseal fraying and cupping seen in the femur and tibia are features of rickets (bottom panels). B) MicroCT surface images of the femur show cortical bone deficiency, which produces a moth-eaten appearance and also confirms hypo-mineralization of condyles in both mutants. The white line in the longitudinal mid-plane sections (B, top) indicates the region where the transverse microCT images were taken (B, bottom).

Copyright

This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711

Associated Alleles

Symbol	Name
Snx10^tm1a(EUCOMM)Raba	sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino
Tcirg1^tm1Ypl	T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Yi Ping Li

Associated Genotypes

Allelic Composition	Genetic Background
Tcirg1^tm1Ypl/Tcirg1^tm1Ypl	involves: 129S4/SvJae * C57BL/6J
Snx10^tm1a(EUCOMM)Raba/Snx10^tm1a(EUCOMM)Raba	involves: 129S4/SvJae * C57BL/6 * C57BL/6J