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Phenotype Image Detail
Image
Caption 3-dimensional reconstructions of proximal femur of wild-type and Lrp5tm3.2Mawa/Lrp5tm3.2Mawa(Lrp5-/-), Hivep3tm1Glm/Hivep3tm1Glm (Shn3-/-) and Lrp5tm3.2Mawa/Lrp5tm3.2Mawa Hivep3tm1Glm/Hivep3tm1Glm (Lrp5-/-,Shn3-/-) mice. Lrp5tm3.2Mawa/Lrp5tm3.2Mawa mice display low bone mass. Lrp5 deletion partially resversed the osteosclerotic bone phenotype exhibited by Hivep3tm1Glm/Hivep3tm1Glm mice.
Copyright This image is from Shim JH, J Clin Invest 2013 Sep 3;123(9):4010-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201597
Associated
Alleles
Symbol Name
Hivep3tm2Glm human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 2, Laurie H Glimcher
Lrp5tm3.2Mawa low density lipoprotein receptor-related protein 5; targeted mutation 3.2, Matthew Warman
Associated
Genotypes
Allelic Composition Genetic Background
Hivep3tm1Glm/Hivep3tm1Glm involves: C57BL/6
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa involves: 129S1/Sv
Hivep3tm1Glm/Hivep3tm1Glm
Lrp5tm3.2Mawa/Lrp5tm3.2Mawa
involves: 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory