Phenotype Image Detail

Image

Caption

Embryonic Ubr4 (p600) is required for liver development. H&E stained transverse sections of control Ubr4^tm1.2Nkt/Ubr4⁺ Edil3^{Tg(Sox2-cre)1Amc}/0 (p600^+/-) (left) and Ubr4^tm1.2Nkt/Ubr4^tm1.2Nkt Edil3^{Tg(Sox2-cre)1Amc}/0 (p600 cKO) (right) liver at days E12.5 (A) and E13.5 (B). Note that the mutant livers have less densely packed parenchymal hepatocytes. Scale bars indicate 100 um.

Copyright

This image is from Nakaya T, PLoS One 2013;8(6):e66269, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:203460

Associated Alleles

Symbol	Name
Edil3^Tg(Sox2-cre)1Amc	EGF-like repeats and discoidin I-like domains 3; transgene insertion 1, Andrew P McMahon
Ubr4^tm1.2Nkt	ubiquitin protein ligase E3 component n-recognin 4; targeted mutation 1.2, Yoshihiro Nakatani

Associated Genotypes

Allelic Composition	Genetic Background
Ubr4^tm1.2Nkt/Ubr4^tm1.2Nkt Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL