Phenotype Image Detail

Image

Caption

Abnormalities in the microvasculature of hearts from Ngf^tm1.1Blhe/Ngf⁺ (proNgf-HA/+) mice. (A-C) Hearts from proNgf-HA/+ mice at postnatal day 9 analyzed for platelet deposition (as assessed by CD41 immunofluorescence, red) compared with wild-type (Ngf+/+) and with Ngfr^tm1Jae/Ngfr^tm1Jae Ngf^tm1.1Blhe/Ngf⁺ (p75-/-;proNgf-HA/+) myocardium. (D-F) ICAM-1 expression (red) in the proNgf-HA/+ myocardium compared with the wild-type and p75-/-;proNgf-HA/+ myocardium, at postnatal day 9. (G-I) FITC-dextran (green) accumulation and extravasation was examined in the myocardium from 3-month-old wild-type, proNgf-HA/+, and p75-/-;proNgf-HA/+ mice. (J and K) Quantification of CD41 and ICAM-1 immunofluorescence (n=3-6 mice/condition, eight fields of view per mouse). *, P< 0.05; **,P < 0.01, mean +/- SEM. Bar, 100 um.

Copyright

This image is from Siao CJ, J Exp Med 2012 Nov 19;209(12):2291-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:190893

Associated Alleles

Symbol	Name
Ngfr^tm1Jae	nerve growth factor receptor (TNFR superfamily, member 16); targeted mutation 1, Rudolf Jaenisch
Ngf^tm1.1Blhe	nerve growth factor; targeted mutation 1.1, Barbara L Hempstead

Associated Genotypes

Allelic Composition	Genetic Background
Ngf^tm1.1Blhe/Ngf^+	B6.Cg-Ngf^tm1.1Blhe
Ngf^tm1.1Blhe/Ngf^+ Ngfr^tm1Jae/Ngfr^tm1Jae	B6.Cg-Ngf^tm1.1Blhe Ngfr^tm1Jae