Phenotype Image Detail

Image

Caption

TrkA+ projections are reduced in Elp1^{tm1c(KOMP)Wtsi}/Elp1^{tm1c(KOMP)Wtsi}H2az2^{Tg(Wnt1-cre)11Rth}/0 (CKO) fetuses. (A-D) E17.5. (A and B) TrkA+ fibers in the dorsal horn of the spinal cord are reduced in CKO fetuses (B) compared with controls (A). (C and D) TrkA+ fibers in the skin are also less prevalent in CKO fetuses compared with wild-type (WT) littermates. (Scale bar: 40 um.)

Copyright

This image is from George L, Proc Natl Acad Sci U S A 2013 Nov 12;110(46):18698-703. Copyright 2013 National Academy of Sciences, U.S.A. J:202989

Associated Alleles

Symbol	Name
Elp1^tm1c(KOMP)Wtsi	elongator complex protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch

Associated Genotypes

Allelic Composition	Genetic Background
Elp1^tm1c(KOMP)Wtsi/Elp1^tm1c(KOMP)Wtsi H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * C57BL/6N * CBA/J