Phenotype Image Detail

Image

Caption

Reduced numbers of sympathetic and dorsal root ganglia (DRG) neurons in Elp1^{tm1c(KOMP)Wtsi}/Elp1^{tm1c(KOMP)Wtsi} H2az2^{Tg(Wnt1-cre)11Rth}/0 (CKO) embryos. (A-K) E17.5. Neuron numbers are significantly reduced in the superior cervical ganglion (SCG) (A-C) and DRG (D and E) in conditional knockout (CKO) embryos compared with controls. (F-K) TrkA+ and substance P+ DRG neurons are depleted in CKO embryos (G and L, respectively), compared with controls (F and H), whereas the number of TrkC+ DRG neurons is slightly increased in mutant embryos (J and K). (Scale bar: 40 um). **P < 0.01.

Copyright

This image is from George L, Proc Natl Acad Sci U S A 2013 Nov 12;110(46):18698-703. Copyright 2013 National Academy of Sciences, U.S.A. J:202989

Associated Alleles

Symbol	Name
Elp1^tm1c(KOMP)Wtsi	elongator complex protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
H2az2^Tg(Wnt1-cre)11Rth	H2A.Z histone variant 2; transgene insertion 11, David H Rowitch

Associated Genotypes

Allelic Composition	Genetic Background
Elp1^tm1c(KOMP)Wtsi/Elp1^tm1c(KOMP)Wtsi H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: C57BL/6J * C57BL/6N * CBA/J