Phenotype Image Detail

Image

Caption

(A) Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Foxg1^tm1(cre)Skm/Foxg1⁺ (Foxg1-Cre;Tbx1-GFP^flox/+) mutants have thymic aplasia, nasal malformations at E15.5, and eye and pharyngeal defects at E11.5. (B) Gt(ROSA)26Sor^{tm1(Tbx1/GFP)Bem}/Gt(ROSA)26Sor⁺ Tg(Pax2-cre)1Akg/0 (Pax2-Cre;Tbx1-GFP^flox/+) mutants die shortly after birth. They have microcephaly and ocular defects. Thymus (T), heart (H), lungs (L), forebrain (FB). (C) Paintfilling of inner ears in Pax2-Cre;Tbx1-GFP^flox/+ and Foxg1-Cre;Tbx1-GFP^flox/+ mutants. The endolymphatic duct (ED) and common crus (CC) are enlarged. The lateral simicircular canal (LC), utricle (U), and saccule (S) are missing. The cochlea (C) is shortened to varying degrees. BAC316.23 mice show similarities in inner ear morphological defects. Anterior canal (AC), posterior canal (PC). (D) Wholemount RNA in situ hybridization at E9.5 for NeuroD, expressed in neuroblasts of the cranial ganglia. Wholemount immunohistochemistry stains cranial sensory ganglia with anti-Neurofilament at E10.5. Red brackets indicate olfactory placode. Otic vesicle is circled in yellow.

Copyright

This image is from Freyer L, BMC Dev Biol 2013 Aug 23;13(1):33, an open-access article, licensee BioMed Central Ltd. J:204435

Associated Alleles

Symbol	Name
Foxg1^tm1(cre)Skm	forkhead box G1; targeted mutation 1, Susan K McConnell
Gt(ROSA)26Sor^tm1(Tbx1/GFP)Bem	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Bernice E Morrow
Tg(Pax2-cre)1Akg	transgene insertion 1, Andrew K Groves

Associated Genotypes

Allelic Composition	Genetic Background
Gt(ROSA)26Sor^tm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor^+ Foxg1^tm1(cre)Skm/Foxg1^+	involves: 129P2/OlaHsd * C57BL/6 * SJL
Gt(ROSA)26Sor^tm1(Tbx1/GFP)Bem/Gt(ROSA)26Sor^+ Tg(Pax2-cre)1Akg/0	involves: 129 * C57BL/6 * SJL