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Phenotype Image Detail
Image
Caption (E) Representative H&E staining of kidney tissues from heterozygous Mmuttm1Cpv/Mmut+ Tg(Alb-Mut)#Cpv/0 (Mut*/-;TgINS-Alb-Mut) vs. Mmuttm1Cpv/Mmuttm1Cpv Tg(Alb-Mut)#Cpv/0 (Mut-/-;TgINS-Alb-Mut) mice fed a high protein diet for 6 months starting at 2-3 until 8-9 months of age [Left vs. Right; black arrows, granular appearance of the cortex (magnification, 10 X); Inset in Right, vacuolar changes of proximal tubular epithelia (40X)].
Copyright This image is from Manoli I, Proc Natl Acad Sci U S A 2013 Aug 13;110(33):13552-7. Copyright 2013 National Academy of Sciences, U.S.A. J:200689
Associated
Alleles
Symbol Name
Mmuttm1Cpv methylmalonyl-Coenzyme A mutase; targeted mutation 1, Charles P Venditti
Tg(Alb-Mut)#Cpv transgene insertion, Charles P Venditti
Associated
Genotypes
Allelic Composition Genetic Background
Mmuttm1Cpv/Mmuttm1Cpv
Tg(Alb-Mut)#Cpv/0
involves: C57BL/6
Mmuttm1Cpv/Mmut+ involves: C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory