Phenotype Image Detail

Image

Caption

(D) The shape of the inner ear was visualized at E12.5 in wild-type (WT) and Fat1^tm1.2Fhel/Fat1^tm1.2Fhel Tg(Myl1-lacZ)1Ibdml/0 (Fat1^{deltaTM/deltaTM}) embryos owing to the Tg(Myl1-lacZ)1Ibdml (MLC3f-2E) transgene, which is expressed in the developing inner ear in addition to differentiating muscles. Micrographs show an area of the face around the ear. This area shows: left: the masserter muscles (unaffected), bottom: a stream of muscle cells migrating subcutaneously from the second brachial arch (future subcutaneous muscles of the face, which migration path is visibly affected); and top right: the inner ear structure with the endolymphatic duct (ed), a long tube oriented dorsally, finishing with an enlarged area called the endolymphatic sac (es). Both the ed and es are reduced in half of mutant inner ears examined (frequently asymmetric).

Copyright

This image is from Caruso N, PLoS Genet 2013 Jun;9(6):e1003550, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:199157

Associated Alleles

Symbol	Name
Fat1^tm1.2Fhel	FAT atypical cadherin 1; targeted mutation 1.2, Francoise Helmbacher
Tg(Myl1-lacZ)1Ibdml	transgene insertion 1, Developmental Biology Institue of Marseilles-Luminy

Associated Genotypes

Allelic Composition	Genetic Background
Fat1^Gt(KST249)Byg/Fat1^Gt(KST249)Byg Tg(Myl1-lacZ)1Ibdml/0	involves: 129P2/OlaHsd