Phenotype Image Detail

Image

Caption

Fetal lungs are immature in Stk40^tm1Nju/Stk40^tm1Nju (Stk40-/-) mice. A, hematoxylin and eosin staining of wild-type (Stk40+/+) and mutant lungs of P0 and E18.5 mice. Scale bars, 50 um. Three lungs for each genotype were serially sectioned and compared. Representative results are shown. C, periodic acid-Schiff staining of E18.5 lungs. The red color indicates the glycogen deposit. Scale bars, 20 um. Three lungs for each genotype were serially sectioned and compared. Representative results are shown. D, BrdU staining of E18.5 lungs. Nuclei were counterstained with hematoxylin. Scale bars, 50 um. Stk40+/? indicates wild-type or heterozygous mice. F, TUNEL staining of E18.5 lungs. Nuclei were counterstained with hematoxylin. Scale bars, 50 um. Arrowheads indicate the positive cells. H, immunohistochemistry (IHC) staining of TTF-1 in paraffin sections of E15.5 lungs. Scale bars, 50 um. All data were normalized to one corresponding wild-type level (set as 1). Stk40+/?, n = 3; Stk40-/-, n = 3. *, p < 0.05; **, p < 0.01. Error bars, S.D.

Copyright

This image is from Yu H, J Biol Chem 2013 Feb 22;288(8):5342-52 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:196001

Associated Alleles

Symbol	Name
Stk40^tm1Nju	serine/threonine kinase 40; targeted mutation 1, Model Animal Research Center of Nanjing University

Associated Genotypes

Allelic Composition	Genetic Background
Stk40^tm1Nju/Stk40^tm1Nju	B6.129-Stk40^tm1Nju