Phenotype Image Detail

Image

Caption

Progressive deterioration in brain and spinal cord of Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0 (Nes Ei24^f/f) mice. (A-B) NissI staining of interneurons (A) and the DCST (dorsal corticospinal tract) region (B) in spinal cords of mutant mice at different ages shows a progressive increase in the number of vacuolated cells and loss of neurons. Bar, 50 um (A, B). (C) Myelin stained by anti-CNPase exhibits progressively irregular arrangement in the cingulate cortex in mutant mice. At 4 months of age, the soma of oligodendrocytes are vacuolated in mutant mice. Bar, 100 um.

Copyright

This image is from Zhao YG, J Biol Chem 2012 Dec 7;287(50):42053-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:193420

Associated Alleles

Symbol	Name
Ei24^tm1Hzha	etoposide induced 2.4 mRNA; targeted mutation 1, Hong Zhang
Tg(Nes-cre)1Kln	transgene insertion 1, Rudiger Klein

Associated Genotypes

Allelic Composition	Genetic Background
Ei24^tm1Hzha/Ei24^tm1Hzha Tg(Nes-cre)1Kln/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL