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Phenotype Image Detail
Image
Caption Cyst development during embryogenesis and the first postnatal month in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha (Pkd1RC/RC) and Pkd1tm1.1Pcha/Pkd1tm1Shh (Pkd1RC/del2) animals. During embryonic development, kidney cysts (*) are detectable in Pkd1tm1.1Pcha/Pkd1tm1Shh mutant mice by E15.5 and Pkd1tm1.1Pcha/Pkd1tm1.1Pcha mutant mice by E16.5. Subsequently, cystogenesis proceeded much more rapidly in Pkd1tm1.1Pcha/Pkd1tm1Shh versus Pkd1tm1.1Pcha/Pkd1tm1.1Pcha animals. Pkd1tm1.1Pcha/Pkd1tm1.1Pcha mice, nonetheless, have a significant cyst burden during renal development and, indeed, have a higher percentage of kidney weight per body weight (%KW/BW) at P15 than at 1 month. This is probably because proximal tube (PT) cysts dominate the cyst burden at the early stages, but then decline as collecting duct (CD) cysts become the major adult disease manifestation. Scale bars: E15.5 = 100 um, E16.6 = 150 um, E18.5 and P1 = 250 um, P15 = 750 um.
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Pkd1tm1Shh polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Shigeo Horie
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha involves: 129S1/Sv * C57BL/6
Pkd1tm1Shh/Pkd1tm1.1Pcha involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/17/2019
MGI 6.14
The Jackson Laboratory