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Phenotype Image Detail
Image
Caption Illustration of disease progression and variation in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha (Pkd1RC/RC) mice. (A) Gross images of wild-type (WT) and homozygous mutant kidneys at 3, 6, 9 and 12 months. Macroscopic cysts become visible by 6 months. Ruler shows the SI unit cm. (B) Masson Trichrome stained kidney histology sections of homozygous mice used for physiological and histological analysis. The illustration highlights the observed disease variability among animals at the same age, and the progressive disease severity throughout aging in these outbred animals. Scale bars = 1 mm.
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha involves: 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory