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Phenotype Image Detail
Image
Caption Pkd1tm1.1Pcha/Pkd1tm1.1Pcha (Pkd1RC/RC) and Pkd1tm1.1Pcha/Pkd1tm1Shh (Pkd1RC/del2) mice show a switch in tubular cyst origin (from proximal tubule to collecting duct) corresponding to age. (A) IF lectin labeling of proximal tubule (PT) (LTA) and collecting duct (CD) (DBA). During early kidney development (P1), cysts originated mainly from PT in Pkd1tm1.1Pcha/Pkd1tm1.1Pcha and Pkd1tm1.1Pcha/Pkd1tm1Shh animals, with only rare CD cysts (arrowheads). Later in development (P12), a switch to more CD cysts occurred that became more prominent after kidney development (P25, Pkd1tm1.1Pcha/Pkd1tm1Shh; 3 months, Pkd1tm1.1Pcha/Pkd1tm1.1Pcha), with only a few remaining PT cysts (arrows). With disease progression, an increasing number of cysts seemed to dedifferentiate. Asterisks indicate a lack of labeling with tubule markers. Scale bars: 100 um (P1); 200 um (P12); 300 um (P25); 500 um (3 months and 12 months).
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Pkd1tm1Shh polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Shigeo Horie
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1.1Pcha/Pkd1tm1.1Pcha involves: 129S1/Sv * C57BL/6
Pkd1tm1Shh/Pkd1tm1.1Pcha involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory