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Phenotype Image Detail
Image
Caption Histology of Pkd1tm1.1Pcha/Pkd1tm1Shh (Pkd1RC/del2) mice highlights early-onset and rapidly progressive cystic disease. Representative Masson Trichrome sections of mutant and wild-type (WT) kidneys from E14.5 to P180 Kidney cysts were clearly visible as early as E16.5 (a few cysts were present at E15.5) and rapidly increased in number/size with age. Glomerular cysts were present as early as E16.5 (insets). The kidneys of animals with longer survival (P180) were highly fibrotic, with little obvious healthy tissue. Scale bars: 100 um (E14.5 to P1); 500 um (P12); 750 um (P25 and P180); 50 um (insets).
Copyright This image is from Hopp K, J Clin Invest 2012 Nov 1;122(11):4257-73 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:193544
Associated
Alleles
Symbol Name
Pkd1tm1.1Pcha polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1.1, Peter Harris
Pkd1tm1Shh polycystin 1, transient receptor poteintial channel interacting; targeted mutation 1, Shigeo Horie
Associated
Genotypes
Allelic Composition Genetic Background
Pkd1tm1Shh/Pkd1tm1.1Pcha involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory