Phenotype Image Detail

Image

Caption

Phenotypic analysis of Cited2^tm1Bha/Cited2^tm1Bha (Cited2-/-) mouse embryos. MRI analysis of embryos 15.5 days post coitum (dpc). Genotypes are indicated as shown. Sagittal sections through the left kidney (A-B) are shown to indicate the left adrenal gland where present (arrows), and absent (arrowhead). Transverse sections through the thorax (F-G) and 3D reconstructions (K-L) are shown to demonstrate cardiac anatomy. Loss of Cited2 leads to adrenal agenesis (B, arrowhead), right atrial isomerism, ventricular septal defect (VSD) and common atrium (G), and abnormal ventricular topology (L). RA, Right Atria; RV, Right Ventricle; LV, Left Ventricle; IVS, Interventricular Septum; IAS, Intra-atrial Septum; AAo, Aorta; AoA, Aortic Arch; Tr, Trachea; DAo, Dorsal Aorta; LSVS and RSVS, Left and Right Systemic Venous Sinus. Axis: A, Anterior; P, Posterior; V, Ventral; D, Dorsal; L, Left; R, Right. Scale bars: 0.5 mm.

Copyright

This image is from Chen CM, PLoS One 2012;7(10):e46256, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:192202

Associated Alleles

Symbol	Name
Cited2^tm1Bha	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; targeted mutation 1, Shoumo Bhattacharya

Associated Genotypes

Allelic Composition	Genetic Background
Cited2^tm1Bha/Cited2^tm1Bha	involves: 129P2/OlaHsd