Phenotype Image Detail

Image

Caption

Rapid and progressive cystic dilation in Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi (Pkd1^V/V) postnatal kidneys. (A) Overview of mutant kidneys of various postnatal stages in H&E-stained sections, with two to three animals analyzed for most of the stages. (Scale bars; 2 mm.) Note the intact papilla tip in P3-P14 kidneys. P22 and P28 kidneys are more enlarged (~15 mm long) with further cystic expansion (data not shown). (B-D) H&E-stained sections of P5, P7, and P14 mutant kidneys, respectively. Note the intact glomeruli and proximal tubule (PT)-like structures. (E) Masson-trichrome (MT)-stained kidney section of P22 mutant mouse. Note the intact glomeruli and PT-like tubules surrounded by interstitial fibrosis. (F) H&E-stained section of P28 mutant kidney. Note the large size of the cysts and intact glomeruli and PT-like tubules (Inset). (G) MT-stained liver section of P14 mutant mouse. Note the fibrosis around the dilated biliary ducts.

Copyright

This image is from Yu S, Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18688-93. Copyright 2007 National Academy of Sciences, U.S.A. J:127628

Associated Alleles

Symbol	Name
Pkd1^tm1.1Fqi	polycystin 1, transient receptor potential channel interacting; targeted mutation 1.1, Feng Qian

Associated Genotypes

Allelic Composition	Genetic Background
Pkd1^tm1.1Fqi/Pkd1^tm1.1Fqi	B6.129S6-Pkd1^tm1.1Fqi