Phenotype Image Detail

Image

Caption

Details of skeletal preparations. (A-D) Vertebral column of control and Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0 (Col2a1-cre;Apc^15lox/15lox) littermates at E14.5 (A,B) and E16.5 (C,D). Mutant vertebrae lacked structural integrity (arrowheads). At E16.5, mineralization was enhanced in the proximal part of the mutant rib (arrow). (E-H) Forelimb of control and mutant littermates at E14.5 (E,F) and E16.5 (G,H). At E16.5, only the scapula was identified (arrowhead), while more distal parts were represented by patchy cartilage aggregations (arrow). (I,J) Skull of control and mutant littermates at E16.5. The mutant displayed mineral deposition in the back skull corresponding to the cartilaginous structure in the control (arrowheads). Scale bars: 3 mm in A-H; 1 mm in I,J.

Copyright

This image is from Miclea RL, BMC Dev Biol 2009;9():26, an open-access article, licensee BioMed Central Ltd. J:149225

Associated Alleles

Symbol	Name
Apc^tm1Rsmi	APC, WNT signaling pathway regulator; targeted mutation 1, Ron Smits
Tg(Col2a1-cre)1Rsjo	transgene insertion 1, Randall S Johnson

Associated Genotypes

Allelic Composition	Genetic Background
Apc^tm1Rsmi/Apc^tm1Rsmi Tg(Col2a1-cre)1Rsjo/0	involves: 129P2/OlaHsd * FVB/N