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Phenotype Image Detail
Image
Caption Histology of erythroid hyperplasia in the bone marrow, increased iron deposition in the liver, and alpha globin chain inclusions in the peripheral blood of adult heterozygous Hbbtm1.1(HBG1,HBB*)Ryan/Hbb+ (gamma beta0/+ KI) mice. The femoral bone marrow cavity is expanded and filled with erythroid cells in adult mutant mice. The liver of mutant mice shows increased levels of iron after Perl's iron staining. Vital staining of peripheral blood with methyl violet demonstrates the presence of alpha globin chain inclusions in the mutant mice.
Copyright This image is from Huo Y, J Biol Chem 2009 Feb 20;284(8):4889-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147906
Associated
Alleles
Symbol Name
Hbbtm1.1(HBG1,HBB*)Ryan hemoglobin beta chain complex; targeted mutation 1.1, Thomas M Ryan
Associated
Genotypes
Allelic Composition Genetic Background
Hbbtm1.1(HBG1,HBB*)Ryan/Hbb+ involves: C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory