Phenotype Image Detail

Image

Caption

Phenotypic alterations in the axial skeleton of mice with a split HoxD cluster. Newborn animals were processed and stained for bone (alizarin red) and cartilage tissues (alcian blue). (A) Incidence of different lumbar vertebral formulae in wild-type, heterozygous (In(2Hoxd11;Itga6)1Ddu/+) and homozygous (In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu) mutant animals. L5/6 and L6/7 indicate unilateral transformations of the first sacral vertebrae. (B) Complete transformation of the first sacral vertebra into a lumbar identity (S1>L7) in a homozygous mutant (right), as compared to the L6 formula observed in wild-type specimen (left). (C) Misalignment of the first rib to the sternum (#) and fusions of sternebrae four and five (*) in a homozygous mutant. (D) Seventh cervical vertebrae (C7) of heterozygous and homozygous animals showing ectopic bony material protruding from the transverse processes (arrowheads).

Copyright

This image is from Tschopp P, PLoS Genet 2009 Mar;5(3):e1000398, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:146752

Associated Alleles

Symbol	Name
In(2Hoxd11;Itga6)1Ddu	inversion, Chr 2, Denis Duboule 1

Associated Genotypes

Allelic Composition	Genetic Background
In(2Hoxd11;Itga6)1Ddu/+	involves: 129S1/Sv * 129X1/SvJ
In(2Hoxd11;Itga6)1Ddu/In(2Hoxd11;Itga6)1Ddu	involves: 129S1/Sv * 129X1/SvJ