About   Help   FAQ
Phenotype Image Detail
Image
Caption Defects of arterial differentiation in Acvrl1 null embryos. (A) Whole-mount Pecam1 immunostaining shows defects of vascular remodeling in the embryo proper (b, d, and f) and yolk sac (h) in Acvrl1tm1Dgen/Acvrl1tm1Dgen (Acvrl1 KO) mice. Arrows indicate intersomitic vessels. Arrowheads indicate a well-branched vascular tree in the yolk sac, which is observed only in wild-type mice. a-f are shown with nuclear DAPI stain. (B and C) Expression of arterial endothelium marker genes, Efnb2 and Gja5/Cx40, diminishes in dorsal aorta of Acvrl1 null embryos (arrowheads in b and d) at E8.5 (B) and E9.5 (C). In contrast, the expression of Cdh5, which is detected both in the arteries and in the veins, is maintained (arrowheads in f). In situ hybridization is shown. (D) Expression of an endothelial marker, Pecam1, is maintained in dorsal aorta of an Acvrl1 null embryo (b) and in the yolk sac (d). Immunohistochemistry is shown. a-d are shown with nuclear DAPI stain. (E) Expression of Sm22/Tagln mRNA and Sm22 protein in the mural layers of dorsal aorta is significantly reduced in Acvrl1 null embryos (arrowheads). In situ hybridization (a and b) and immunohistochemistry (c and d) are shown. Insets in C and E show magnified views of dorsal aorta. c and d are shown with nuclear DAPI stain. (Scale bars: A-C and D, a and b, 50 um; and D, c and d, and E, 20 um.)
Copyright This image is from Somekawa S, Proc Natl Acad Sci U S A 2012 Jul 24;109(30):12064-9. Copyright 2012 National Academy of Sciences, U.S.A. J:186473
Associated
Alleles
Symbol Name
Acvrl1tm1Dgen activin A receptor, type II-like 1; targeted mutation 1, Deltagen
Associated
Genotypes
Allelic Composition Genetic Background
Acvrl1tm1Dgen/Acvrl1tm1Dgen involves: 129P2/OlaHsd * C57BL/6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory