Phenotype Image Detail

Image

Caption

Mecp2 deficiency results in placenta abnormalities. The top panels (a-d) show placenta stained with hematoxylin and eosin. The inset shows the section at higher magnification. Arrows show apoptotic cells. The middle panels (e-h) show TUNEL staining of the same sections. Apoptotic nuclei appear as multiple spots (yellow) indicating DNA fragmentation. Propidium iodide was used as a counterstain. An increase the number of TUNEL-positive cells and cleaved caspase 3-positive cells was observed in the placentas of Mecp2^tm1.1Mitoh/Mecp2⁺ (X^e2-X^wt--female) and Mecp2^tm1.1Mitoh/Y (X^e2-Y-male) embryos having a maternal Mecp2^tm1.1Mitoh allele.

Copyright

This image is from Itoh M, J Biol Chem 2012 Apr 20;287(17):13859-67 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:184364

Associated Alleles

Symbol	Name
Mecp2^tm1.1Mitoh	methyl CpG binding protein 2; targeted mutation 1.1, Masayuki Itoh

Associated Genotypes

Allelic Composition	Genetic Background
Mecp2^tm1.1Mitoh/Y	Not Specified
Mecp2^tm1.1Mitoh/Mecp2^+	Not Specified