Phenotype Image Detail

Image

Caption

(A) Table showing the frequency of cardiac abnormalities identified in Gata4^tm1Grg/Gata4⁺ (Gata4 G295S^ki/wt) mice (n = 9) and wild-type littermates (n = 12). Representative images of color (B, D, E, I, J) and pulsed wave Doppler (C, F, G, K, L) findings are shown. Small atrial communication demonstrated by both (B) color and (C) pulsed wave Doppler in heterozygous mutant mouse. Color Doppler recordings across normal aortic valve of a wild-type mouse (D) and stenotic aortic valve of heterozygous mutant mouse (E). Pulsed Doppler waveforms of flow across the aortic valve in wild-type (F) and heterozygous mutant (G) mice demonstrate increased aortic velocity in mutant mice. (H) Scatter plot showing aortic velocities in wild-type and heterozygous mutant mice. Four mutant mice with aortic stenosis are indicated in red. Color Doppler recordings across pulmonary valve of a wild-type (I) and stenotic pulmonary valve in mutant mice (J). Pulsed Doppler waveforms across pulmonary valve of wild-type (K) and mutant mice (L) show increased velocity in mutant mice. (M) Scatter plot showing velocity across pulmonary valve in wild-type and mutant mice. Two mutant mice with pulmonary stenosis indicated in red.

Copyright

This image is from Misra C, PLoS Genet 2012 May;8(5):e1002690, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:185124

Associated Alleles

Symbol	Name
Gata4^tm1Grg	GATA binding protein 4; targeted mutation 1, Vidu Garg

Associated Genotypes

Allelic Composition	Genetic Background
Gata4^tm1Grg/Gata4^+	involves: 129 * C57BL/6