Phenotype Image Detail

Image

Caption

Whole-mount triple fluorescence confocal microscopy of embryonic back skin was performed with antibodies to PECAM-1 (red), LYVE-1 (green), and TER-119 (blue) at E14.5 (A-I) and E17.5 (J-L). A-F, whereas blood vessels visualized by PECAM-1 staining appear unaffected in Clec1b^tm1.1Ksi/Clec1b^tm1.1Ksi (CLEC-2^-/-) mutant embryos, lymphatic vessels visualized by LYVE-1 staining are disorganized and distended in mutant embryos. Lymphatic vessels are filled with TER-119+ erythrocytes (arrows) in mutant embryos. G-L, abnormal connection sites (arrowheads) between blood and lymphatic vessels were detected in mutant embryos. Scale bars = 100 um.

Copyright

This image is from Suzuki-Inoue K, J Biol Chem 2010 Aug 6;285(32):24494-507 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:165898

Associated Alleles

Symbol	Name
Clec1b^tm1.1Ksi	C-type lectin domain family 1, member b; targeted mutation 1.1, Katsue Suzuki-Inoue

Associated Genotypes

Allelic Composition	Genetic Background
Clec1b^tm1.1Ksi/Clec1b^tm1.1Ksi	involves: C57BL/6