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Caption Morphology of mitochondria in normal and respiratory chain-deficient dopamine neurons. (A) Confocal images of YFP-labeled mitochondria in dopamine neurons of 8-wk-old control (genotype Slc6a3tm1(cre)Lrsn/Slc6a3+ Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+) and MitoPark (genotype Tfamtm1Lrsn/Tfamtm1Lrsn Slc6a3tm1(cre)Lrsn/Slc6a3+ Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+) mice. Dopamine neurons also are identified by being TH immunoreactive (red). The detector gain of the YFP signal was decreased in the lower panel to prevent overexposure of the large aggregates. (B) Quantification of mitochondrial morphologies in neurons of control and MitoPark mice at 8 and 14 weeks of age. Data are normalized to the total numbers of cells counted separately. (C) Mito-Park dopamine neuron expressing mito-YFP and labeled with an antibody against the mitochondrial matrix protein SOD2 (red). (D) Mitochondrial aggregates immunolabeled with an antibody against the mitochondrial outer membrane protein TOM20 (red). (Scale bar: 10 um in A; 5 um in C and D.)
Copyright This image is from Sterky FH, Proc Natl Acad Sci U S A 2011 Aug 2;108(31):12937-42. Copyright 2011 National Academy of Sciences, U.S.A. J:176022
Symbol Name
Gt(ROSA)26Sortm1Lrsn gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Nils-Goran Larsson
Slc6a3tm1(cre)Lrsn solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Nils-Goran Larsson
Tfamtm1Lrsn transcription factor A, mitochondrial; targeted mutation 1, Nils-Goran Larsson
Allelic Composition Genetic Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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