Phenotype Image Detail

Image

Caption

ABHD5 (CGI-58) deficiency disrupts the epidermal permeability barrier and affects keratinocyte differentiation. A, euthanized newborn wild-type, Abhd5^tm1.1Rze/Abhd5^tm1.1Rze (Cgi-58-/-), and Pnpla2^tm1Rze/Pnpla2^tm1Rze (Atgl-/-) mice were immersed for 4 hours in toluidine blue dye solution, rinsed with PBS, and photographed. B, skin sections of newborn wild-type and Abhd5^tm1.1Rze/Abhd5^tm1.1Rze mice were stained with antibodies specific for cytokeratin 14 (CK14), cytokeratin 6 (CK6), fillagrin (Fila), or Ki67 and analyzed by light microscopy. Scale bars represent 50 um.

This image is from Radner FP, J Biol Chem 2010 Mar 5;285(10):7300-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:160725

Associated
Alleles

Symbol	Name
Abhd5^tm1.1Rze	abhydrolase domain containing 5; targeted mutation 1.1, Rudolf Zechner
Pnpla2^tm1Rze	patatin-like phospholipase domain containing 2; targeted mutation 1, Rudolf Zechner

Associated
Genotypes

Allelic Composition	Genetic Background
Abhd5^tm1.1Rze/Abhd5^tm1.1Rze	involves: 129P2/OlaHsd * C57BL/6
Pnpla2^tm1Rze/Pnpla2^tm1Rze	involves: 129P2/OlaHsd

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23