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Phenotype Image Detail
Image
Caption Ultrastructure of Prkcitm1Kido/Prkcitm1.1Kido Tg(Nphs1-cre)33Mska/0 podocytes. (A) Although fine foot processes and slit diaphragms are observed at P0 (arrowheads), the foot processes form irregular adhesions and slit diaphragms are apically mislocalized at P7 (arrows). Mutant podocytes at P10 demonstrates effacement of foot processes and irregular adhesions between foot processes (asterisks). Apparently, these adhesions did not form tight junctions. The glomerular basement membrane (GBM) is not significantly affected. US, urinary space; EnC, endothelial cell; CL, capillary lumen. Bars, 200 nm. (B) Immunogold electron microscopy in mutant podocytes at P7 reveals that podocalyxin (5-nm gold particles) loses its apically restricted localization, whereas ZO-1 (10-nm gold particles) localizes at the cell-cell junctions of podocytes (arrows). US, urinary space; CL, capillary lumen. Bar, 200 nm.
Copyright This image is from Hirose T, PLoS ONE 2009;4(1):e4194, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:144995
Associated
Alleles
Symbol Name
Prkcitm1.1Kido protein kinase C, iota; targeted mutation 1.1, Yoshiaki Kido
Prkcitm1Kido protein kinase C, iota; targeted mutation 1, Yoshiaki Kido
Tg(Nphs1-cre)33Mska transgene insertion 33, Taiji Matsusaka
Associated
Genotypes
Allelic Composition Genetic Background
Prkcitm1Kido/Prkcitm1.1Kido
Tg(Nphs1-cre)33Mska/0
involves: C57BL/6 * C57BL/6N * DBA/2

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory