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Phenotype Image Detail
Caption A, H&E-stained mouse brain showing a representative section that was stained in experiments detailed below. The box highlights the image magnified in panel B. Ob, olfactory bulb; Hyp, hypothalamus; Cor, cortex; Hip, hippocampus; Cb, cerebellum; PM, pons-medulla. Scale bar, 240 um. B, shown is a magnified image of a H&E section of mouse cerebellum. The box indicates a representative area of cerebellum stained for all subsequent analyses of all genotypes. Scale bar, 60 um. Immunohistochemical staining was performed on the Purkinje cell layer of serially sectioned wild-type (WT) (C and F), Sparcl1tm1Pmc/Sparcl1tm1Pmc (hevin-null) (D and G), and Adamts4tm1Dqp/Adamts4tm1Dqp (ADAMTS4-null) (E and H) mouse brains. Sections were stained with anti-calbindin (green). Altered morphology of Purkinje cell dendritic processes (arrows) is apparent in Sparcl1tm1Pmc/Sparcl1tm1Pmc (hevin-null) and Adamts4tm1Dqp/Adamts4tm1Dqp (ADAMTS4-null) tissue. Images are representative of staining patterns seen in three independent experiments. PC, Purkinje cell. Scale bar, 1um.
Copyright This image is from Weaver MS, J Biol Chem 2010 Feb 19;285(8):5868-77 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:159752
Symbol Name
Adamts4tm1Dqp a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4; targeted mutation 1, Duanqing Pei
Sparcl1tm1Pmc SPARC-like 1; targeted mutation 1, Peter J McKinnon
Allelic Composition Genetic Background
Sparcl1tm1Pmc/Sparcl1tm1Pmc involves: 129S1/Sv
Adamts4tm1Dqp/Adamts4tm1Dqp involves: 129X1/SvJ * C57BL/6J

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