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Phenotype Image Detail
Caption Npas4tm1Ooe/Npas4tm1Ooe brain shows increased vulnerability to a typical nerve-stress, glutamate excitotoxicity. 15-week-old Npas4tm1Ooe/Npas4tm1Ooe (NXF-KO) mice and wild-type (Wild) littermates were dosed with a glutamate analogue, kainate (28 mg/kg, intraperitoneal) (K1-8 for mutant, WK1-10 for Wild) or saline (S1-8 for KO, WS1-10 for Wild, only S1 and WS1 shown as representative). Microscopic images show glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus (a part of CA1-2 and the DG region), one of the most sensitive sites for glutamate excitotoxicity. Three mutant mice (K6, -7, and -8) died by the fifth day after the kainate injection, whereas no control mice died.
Copyright This image is from Ooe N, J Biol Chem 2009 Jan 9;284(2):1057-63 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:145569
Symbol Name
Npas4tm1Ooe neuronal PAS domain protein 4; targeted mutation 1, Norihisa Ooe
Allelic Composition Genetic Background
Npas4tm1Ooe/Npas4tm1Ooe involves: 129/Sv * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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