Phenotype Image Detail

Image

Caption

Autoimmune disease in mutant mice. (A) Splenomegaly and lymphadenopathy observed in both Mir146^tm1.1Bal/Mir146^tm1.1Bal and Mir146^tm2.1Bal/Mir146^tm2.1Bal mice. Photographs of spleens and peripheral lymph nodes removed from a single representative wild-type (WT) and knockout (KO) mouse. (D) Multiorgan inflammation in homozygous mutant mice. Hematoxylin- and eosin-stained sections of liver and kidney from WT (top) and mutant (middle, low magnification; bottom, high magnification) mice. Note the leukocytic infiltrates in the KO liver (circled with dashed lines), compared with a relatively spared portal triad (PT) in the WT liver. At higher magnification, degenerated hepatocytes (marked by arrows) displaying fragmented nuclei and eosinophilic cytoplasm indicate tissue damage caused by the inflammatory infiltrates. Note the large infiltrate of inflammatory cells (circled) in the mutant kidney. In the low-power image, the KO tubules appear more eosinophilic, and their lumina are dilated. At higher magnification, a degenerated tubule (marked by arrows) indicates tissue damage caused by the inflammatory infiltrates. Bars: (top and middle) 200 um; (bottom) 40 um.

Copyright

This image is from Boldin MP, J Exp Med 2011 Jun 6;208(6):1189-201, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:173671

Associated Alleles

Symbol	Name
Mir146^tm1.1Bal	microRNA 146; targeted mutation 1.1, David Baltimore
Mir146^tm2.1Bal	microRNA 146; targeted mutation 2.1, David Baltimore

Associated Genotypes

Allelic Composition	Genetic Background
Mir146^tm1.1Bal/Mir146^tm1.1Bal	involves: C57BL/6 * FVB/N
Mir146^tm2.1Bal/Mir146^tm2.1Bal	involves: 129S1/Sv * C57BL/6 * FVB/N