Phenotype Image Detail

Image

Caption

(C) Representative spleen sizes (top left) and weight calculated from seven to nine mice per genotype, either Commd10^{Tg(Vav1-icre)A2Kio}/0 (VavCre), Rc3h1^tm1.1Mass/Rc3h1⁺ Commd10^{Tg(Vav1-icre)A2Kio}/0 (VavCre Rc3h1^F/Wt) or Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Commd10^{Tg(Vav1-icre)A2Kio}/0 (VavCre Rc3h1^F/F) (bottom left). (right) Total splenocyte (n = 9-11), B cell (B220⁺; n = 9-11), naive CD4 and CD8 T cell (CD44^lo CD62L^hi; n = 9-7), neutrophil (Neu; Mac1⁺Gr1^hiSiglecF^-; n = 4-6), and DC (CD11c⁺; n = 4-6) numbers in spleens of mice of the indicated genotypes. Error bars indicate SD.

Copyright

This image is from Bertossi A, J Exp Med 2011 Aug 29;208(9):1749-56, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:177784

Associated Alleles

Symbol	Name
Commd10^Tg(Vav1-icre)A2Kio	COMM domain containing 10; transgene insertion A2, Dimitris Kioussis
Rc3h1^tm1.1Mass	RING CCCH (C3H) domains 1; targeted mutation 1.1, Marc Schmidt-Supprian

Associated Genotypes

Allelic Composition	Genetic Background
Rc3h1^tm1.1Mass/Rc3h1^tm1.1Mass Commd10^Tg(Vav1-icre)A2Kio/Commd10^+	involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL